产品Product

SARS-CoV-2 S Protein RBD (Mammalian, Mu, B.1.621, C-mFc)

Recombinant SARS-CoV-2 S Protein RBD (Mu, B.1.621, C-mFc)


Catalog #: DRA183    Derived From: Human Cells


Description: 

Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541 (R346K, E484K, N501Y) is expressed with a 6His tag at the C-terminus. R346K, E484K and N501Y mutations were identified in the SARS-CoV-2 variant (known as B.1.621/Mu lineage) which emerged in Columbia.

Accession: P0DTC2

Known as: SARS-CoV-2 RBD Protein; SARS-CoV-2 Spike RBD Protein; SARS-CoV-2 S Protein RBD


Quality Control:

Mol Mass: 51.5kDa    AP Mol Mass: 55-65kDa, reducing conditions

Purity: Greater than 95% as determined by reducing SDS-PAGE.


Formulation:

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4


Shipping:

The product is shipped on dry ice pack.

Upon receipt, store it immediately at the temperature listed below.


Storage:

Reconstituted protein solution should be stored at  ≤ -20°C.


Purification: 
Affinity purification chromatography


Application:
Immunogen, calibrator or standard.


Background:

The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.


FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY





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