Recombinant Treponema pallidum (strain Nichols) Outer Membrane Protein TP0453 is produced by our E.coli expression system and the target gene encoding Cys25-Ser287 is expressed with a 6His tag at the N-terminus.
Known as: Outer membrane protein TP0453; TPANIC_0453; 30kLP; TP_0453; TP0453
TP0453 is the only lipoprotein in T. pallidum known to be associated with the outer membrane (OM). Syphilis is a multistage, sexually transmitted illness caused by the spirochetal pathogen Treponema pallidum, an extracellular, highly motile bacterium. Membrane integration of the TP0453 polypeptide was found to increase membrane permeability, suggesting the molecule functions in a porin-like manner.TP0453 is a novel bacterial lipoprotein whose amphiphilic behavior may contribute to T. pallidum OM biogenesis. And TP0453 is also a novel type of bacterial outer membrane protein which may render the T. pallidum outer membrane permeable to nutrients while remaining inaccessible to antibody.