Source: Cultured in vitro under conditions free from animal derived components.
Product buffer solution: PBS, pH 7.4
Shelf life and storage: 24 months from manufacturing at <-20 °C; 1 month, 2 to 8 °C under sterile conditions.
Analyte Description: CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
PARAMETERS TESTED ON EACH LOT
Product appearance: Liquid, may turn slightly opaque during storage
Product concentration: 5.0 mg/ml (+/- 10 %)
Immunoreactivity: 80–120 % compared to the reference sample in an ELISA test.
Purity: ≥95 %
Please note that pair recommendations are based on results obtained by our laboratory. Equally good results may be obtained using other pairs and therefore these recommendations are only indicative.