产品Product

神经生物学

Human NNE (诊断原料,神经生物学)

Recombinant Human NNE 


Catalog # DRA05        Derived From: E.coli   


Description:

Recombinant Human NNE is produced by E.coli expression system and the target gene encoding Met1-Lys434 is expressed with a 6His tag at the N-terminus.

Accession:  P06733

Names(Known as):Non-neural enolase(NNE);MPB-1;MBP-1;Enolase 1;Plasminogen-binding protein;Phosphopyruvate hydratase;2-phospho-D-glycerate hydro-lyase;C-myc promoter-binding protein


Quality Control:

Mol Mass:  48kDa          AP Mol Mass:  45-55kDa, reducing conditions

Purity:  Greater than 95% as determined by reducing SDS-PAGE.


Formulation:

Supplied as a 0.2 μM filtered solution of 20mM Tris, 250mM NaCl, 1mM MgSO4,20% glycerol,pH7.5.


Shipping:

The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.


Storage:

Reconstituted protein solution should be stored at ≤ -20°C.


Purification: 
Affinity purification chromatography.


Immunoreactivity: 
N.A.


Application:
Immunogen, calibrator or standard.


Background:

Non-neuronal enolase is a glycolytic enzyme composed of homodimeric alpha enolase subunits and is expressed in most human tissues. Enolase is a glycolytic enzyme that catalyzes the dehydratation of 2-phosphoglycerate to phosphoenolpyruvate, in the last steps of the catabolic glycolytic pathway.ENO1 overexpression has been associated with multiple tumors, including glioma, neuroendocrine tumors, neuroblastoma, pancreatic cancer, prostate cancer, cholangiocarcinoma, thyroid carcinoma, lung cancer, hepatocellular carcinoma, and breast cancer.In many of these tumors, ENO1 promoted cell proliferation by regulating the PI3K/AKT signaling pathway and induced tumorigenesis by activating plasminogen.


FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY



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