产品Product

神经生物学

Human S100B (诊断原料,神经生物学)

Recombinant Human S100B 


Catalog # DCM19        Derived From: E.coli   


Description:

Recombinant Human S100 Calcium Binding Protein B/S100B (N-6His) is produced by E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus.

Accession:  P04271

Names(Known as):Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100b; S100 beta; S100 calcium binding protein B


Quality Control:

Mol Mass:  12.2kDa                  AP Mol Mass:  12kDa, reducing conditions

Purity:  Greater than 95% as determined by reducing SDS-PAGE.


Formulation:

Supplied as a 0.2 μM filtered solution of 20mM PBS,150mM NaCl,pH7.4.


Shipping:

The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.


Storage:

Reconstituted protein solution should be stored at ≤ -20°C.


Purification: 
Affinity purification chromatography.


Immunoreactivity: 
N.A.


Application:
Immunogen, calibrator or standard.


Background:

S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in human melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.


FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY



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